The past decade has seen increasing use of peripheral nerve block for the patients after total knee arthroplasty (TKA). The use of femoral nerve blocks, either continuous or single-shot, emerged as an alternative approach to postoperative pain management. The outcomes generated by the use of femoral nerve block include satisfactory analgesia without side effects associated with opiates and ketamine (i.e., respiratory depression, hemodynamic effects, and decreased use of antiemetics or oversedation); shorter length of stay; faster recovery as well as functional rehabilitation. The purpose of this review of literature is to address the following question: How effectively can use of femoral block in the patients with TKA control the postoperative pain? The critical appraisal of 6 research articles with the strongest level of evidence showed that the use of femoral block neither significantly relieves postoperative pain nor improves other postoperative outcomes after knee replacement so their administration should be discouraged.