Intelligent Drug Delivery Get Your Medicine Through Your Teeth

Patton, Maria, Chandni Oza, and Neta Mance


The purpose of this project is to compare the ease of use and effectiveness between the traditional methods of drug administration and new delivery systems through the use of an intraoral prosthesis.


Controlling the delivery of needed medications achieves more effective therapies and eliminates the potential for both under- and overdosing. However, it is always easier said than done. Many of the traditional modes of drug administration incorporate verbal and print instructions directing patients toward the consumption of the correct drug dosage. These methods can cause problems especially in the area of patient compliance and the ability of the patient to retain such instructions. The aim of this study is to look at the effectiveness of intraoral appliances as a containment unit and automatic delivery system of a chosen medication. A search through available literature was conducted to identify different designs by various companies that have patented such intraoral appliances. It was found that the benefits of using controlled-delivery systems include the maintenance of drug levels within a desired range, the need for fewer administrations, optimal use of the drug in question, and increased patient compliance. While these advantages can be significant, the potential disadvantages cannot be ignored: the possible toxicity or nonbiocompatibility of the materials used, undesirable by-products of degradation, any surgery required to implant or remove the system, the chance of patient discomfort from the delivery device, and the higher cost of controlledrelease systems compared with traditional pharmaceutical formulations.


The Intelligent drug delivery system is a major innovation in the field of portable drug delivery. The advantages of such a system include maintenance of drug levels, less administrations, optimal use of the drug and last but not least increased patient compliance. The ease of use and effectiveness of this new delivery system through intraoral prosthesis compared to the more traditional method of drug delivery is truly remarkable for the intended patients.